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21 janvier 2019
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01 décembre 2018
Updated21 janvier 2019
Étude de l’utilité d’une biopsie systématique à un an post-greffe sur la survie patient/greffon des patients transplantés rénaux
Dion Angélina - Stagiaire M2 - M2 MPCE
Routine biopsies realized for all transplanted at a given time, may be useful for fortuitously detect subclinical lesions and thus improve graft survival. However, the biopsy may cause complications and, for certain lesions, there is no consensual procedures to follow. The clinical utility of routine biopsy at one year post-transplant on the survival of the patient / graft is widely discussed. From the DIVAT cohort, we studied the transplant survival of patients with or without routine biopsy at one year post-transplant. The primary analysis compares biopsied patients of biopsieurs centers and patients of not biopsieurs centers, from 1182 patients (33 % with a biopsy). In the secondary analysis, we are interested in the survival of patients biopsied and not biopsied of biopsieurs centers, from 817 patients (48 % with a biopsy). In the primary analysis, we do not bring out of differences in survival between center groups (biopsieurs vs. no). In the secondary analysis, have a systematic biopsy at one year appears to protect patients from the risk of death. This difference in survival is certainly due to poorer health of not biopsied patients, explaining that they did not a biopsy and a higher risk of death.
Keywords: kidney transplantation, systematic biopsy at 1 year, survival analysis.
Début : Avril 2015
Fin : Septembre 2015